Vriska and Rose is maybe like the best "currently only theoretical" kismesis in existence. They are both just so utterly hellbent. Damara<3<Meenah is also kind of insanely good and slept on.

I also have kind of a soft spot for like... Snowman/Slick? Idk. I just think it's sweet that they hate each other so much, but in the end, they show these forms of... like... macabre kindness? To each other. Yknow? The way Snowman shows up and casually stops Slick from being gunned down, as if that's not anybody else's right to do but her. The way Slick puts a bullet through her heart in Cascade at her bidding, freeing her from centuries of demeaning servitude in the shackles placed upon her by Scratch/English. Pure pitch. Such devotion.