I know its a vision that is very shared but Homestuck is a story that works in such a specific way for the medium its told that unless they go for a total re-imagination of the whole narrative and a different storyline there is no way in hell it can give us a proper adaptation of the comic itself
Honestly i see the most possible way they could replicate the feeling is doing some mixed media stuff a la Amazing world of gumball, it would be interesting to see stuff like full on anime sequences or stop motion