Generally I have not found myself personally offended by some of the jokes removed. I feel like the f-slur is kind of a grey area that doesn't instantly demarcate bigotry. But in general I think that if it makes peoples readers experiences better, then go for it.

I do think there's a good point being made by Danya about how bigotry *as a character's trait* can be important, but even then like, there's enough supporting evidence that Karkat is an asshole without Karkat specifically (mis)using the word 'autistic', and ableism is generally not a key character trait of his unlike say Cronus where his not-even-slightly repressed bigotry and disdain for Mituna in particular is important to understanding him as the rancid character he is.