I wasn't comfortable with the way the other characters talked about Jade and her "dog parts" lol that just made me feel like they weren't really taking it serious or they were making it a big joke or slightly dehumanizing her. But other than that, I have absolutely no issues with other trans characters in Homestuck. I really liked the small side story with Roxy and Callie exploring their genders together that was really nice how they wrote them (also they're just very cute)