I have two fandoms with very low notoriety that I ADORE: DragonFable (2006 browser based flash RPG by the same people who made AdventureQuest) and PKNA ("PaperiniK Nuove Avventure", an Italian comic series about Donald Duck's superhero identity Paperinik, notably including his long time fight against an alien threat from the planet Evron). I've thought about a session involving the four most important characters:

From left to right:

1. Paperinik (PK), the secret superhero identity of Donald Duck. He faces countless challenges over the course of the series, and grows with each one - Page of Hope, Prosbit Dreamer

2. Lyla Lay, a droid with human(duck?)-like intelligence from the 23rd century, undercover in the 20th century on behalf of the Time Police to report chrono criminals (I'm not making this up, this was an official Disney publication) - Heir of Heart, Derse Dreamer

3. One (or Uno in Italian), an advanced artificial intelligence created by the mysterious billionaire inventor Everett Ducklair. He plays a major part of almost every story and is PK's primary ally, supplying him with high-tech weapons and gadgets as well as guidance and advice - Seer of Space, Prosbit Dreamer

4. Xadhoom, formerly called Doctor Xado on her home planet Xerba, where she was the leader of the scientific society before the Evronians invaded the planet. She survived because she happened to be on a trip to Xerba's sun, where she performed an experiment that turned her into a thermonuclear superbeing. She's sworn to use her powers to exterminate the Evronians, and took the name "Xadhoom" which means "creditor", because she wants payback - Witch of Light, Derse Dreamer

They'd have a very good chance of a successful session. They're all great at teamwork, One is the perfect coordinator, and Xadhoom already has First Guardian-level powers. The biggest obstacle is that Paperinik would be unwilling to let the Reckoning destroy the Earth. He would probably insist on trying to save everyone, and would get a bunch of other people involved to try and stop the apocalypse. The whole thing would involve a ton more characters and locations outside the game than most sessions.