Oh dear lord - Doctor Who! How about an all-Gallifreyan roster? (None of them get to be Lord of Time, and they're not happy about it.)

Blue Team:

The Doctor: Knight of Time

Romana: Heir of Mind

Red Team:

The Master: Prince of Space

The Rani: Witch of Life

Utter mayhem ensues but they win anyway, with the help of blatant cheating. Romana and the Rani get on quite well to start with as they're both total nerds, but come to blows over ethical matters. Near the end, the Doctor and Master have to stop fighting each other and make an alliance. They shake on it, but the Master inevitably tries to betray him at the last moment, only to find himself trapped outside the Universe on a rapidly-disintegrating asteroid as the credits roll.