Personally, I'm gonna make a wild guess that there's going to be some kind of divide; some fans will end up being Homestuck (comic) purists while others won't care, and some fans will end up being Homestuck (show) purists.

It'll spark some kind of outrage amongst the fandom, plus most fans I've seen don't seem to have actually read the comic... 0_0

Then there are going to be people like me who will enjoy any medium in which we can consume Homestuck content.

I'm mostly wondering how they're gonna work in the class+aspect system and if they're gonna expand on it in the show or if they're gonna bullshit us some more on that front. I really hope that with HSBC and the Homestuck show we'll get more info on how they actually work, but chances are that it'll just lead to more speculation, which will lead to more divide, which will lead to less people wanting anything to do with Homestuck because the fandom can't calm the fuck down for long enough to agree on anything.

All-in-all: I think the show will be a good thing for us as fans, but a bad thing for us as a fandom.