I have a few different ideas about this.

First off, we could talk about how Homestuck itself looks at irony and apply that to the irony of former/satellite fans. The average person who doesn't like Homestuck... just doesn't engage with Homestuck. There's something in there that the self-proclaimed non-fans want but they don't want people to know they want it. But the mask of irony is the smallest possible amount of distance you can put between yourself and something else.

To comment on jakemorph's post, the worst part about people complaining that Act 6 is too meta is that the meta stuff happens long before Act 6. WV is initially a reader surrogate who gets thrust into being a part of Homestuck. John visits mspaintadventures.com in Act 1. But because the author didn't sit down and explain it to another character, it's ignored. Now if somebody took grievance with author avatars sitting down and explaining things to in-universe characters, I could concede that take. I could also argue that writing in general can be described as an author sitting down and explaining things.

Elaborating on my use of "satellite fans." A group worth separating to discuss more in-depth would be the capital f Fandom. We typically use the word fandom to describe fans of a piece of media and the surrounding culture. However, there is a Fandom culture all to itself that spans across multiple interests. Characters sanded down into both bland and highly specific archetypes for fanfic. The same standards and criticisms levied onto wildly different pieces of media. I strongly disagree with the notion that Hussie holds contempt for Homestuck readers. But her disdain for Fandom is loud and visible.