Cate Wurtz (lamezone.net) was my introduction to webcomix when I was 14, and her work is super awesome. her style is this weird but beautifully executed mix of traditional and digital art alongside image manipulation and a bunch of other cool shit.

Crow Cillers is her magnum opus, but the earlier stuff like smokes and Asscastle is super fun too.

Cate's work tends to dwell into very dark and mature topics tho, so I can't recommend it to EVERYONE, but some people might like it :P~