i've read a wholllle bunch of old shitty video game sprite comics and a lot of them are actually KIND OF endearing. Especially Tales of the Cave, a Cave Story sprite comic that not only references Problem Sleuth a couple times but predated Homestuck by mere months (unfortunately, the entire second half of the comic is lost media :( ). Otherwise, I'll suggest three:

Breaking Cat News (yes, seriously, it's phenomenal)

3D Workers Island (it counts shut up)

XKCD (boring answer I know but is good)

Secret fourth suggestion: Living With A Monster